Sorafenib Free Base
Sorafenib
CAS: 284461-73-0
Molecular Formula: C21H16ClF3N4O3
Sorafenib Free Base - Names and Identifiers
| Name | Sorafenib |
| Synonyms | Nexavar NEXAVAR Forafenib Sorafenib BAY43-9006 Sorafenib-d4 Sorafenib base nexavar,sorafenib Sorafenib Free Base Sorafenib free base(Bay43-9006) Sorafenib free base for research N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea 4-[4-[[4-Chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 4-methylbenzenesulfonate |
| CAS | 284461-73-0 |
| EINECS | 608-209-4 |
| InChI | InChI=1/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10) |
Sorafenib Free Base - Physico-chemical Properties
| Molecular Formula | C21H16ClF3N4O3 |
| Molar Mass | 464.82 |
| Density | 1.454±0.06 g/cm3(Predicted) |
| Melting Point | 202-204°C |
| Boling Point | 523.3±50.0 °C(Predicted) |
| Flash Point | 270.3°C |
| Water Solubility | 100μg/L at 20℃ |
| Solubility | Soluble in DMSO (~20 mg/ml), Hot Methanol, DMF (~20 mg/ml), 1:2 solution of DMSO:PBS(PH |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White to off-white solid |
| Color | White to Off-White |
| pKa | 12.89±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Use | An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway |
Sorafenib Free Base - Risk and Safety
| Risk Codes | R68/20/21/22 - R37/38 - Irritating to respiratory system and skin. |
| Safety Description | S36 - Wear suitable protective clothing. S37 - Wear suitable gloves. S39 - Wear eye / face protection. |
| HS Code | 29350090 |
Sorafenib Free Base - Reference
| Reference Show more | 1. Huang Yule, Gui, Shuangying, storing Xiaoqin. Optimization of formulation and process of sorafenib PLGA-TPGS polymer nanoparticles by Box-Behnken response surface methodology [J]. Journal of Anhui University of Traditional Chinese Medicine, 2019, 38(01):80-86. 2. Liu bojia, Ning Qing, Zhong Rongling, Xia Zhi, Jiang Ziyu, Song Jie, Wei Yingjie. Effect and mechanism of Lupin on invasion and metastasis of human hepatocellular carcinoma cell line HepG2 and SK-HEP-1 [J]. Chinese Journal of Traditional Chinese Medicine, 2020,45(24):6028-6035. 3. [IF = 10.435] Li Zhe et al.Sorafenib and triptolide loaded cancer cell-platelet hybrid membrane-camouflag liquid line. J Nanobiotechnol. 2021 Dec;19(1):1-12 |
Sorafenib Free Base - Introduction
Sorafenib are multiplex kinase inhibitors of Raf-1, B- Raf, and VEGFR-2 with IC50 of 6 nM, 22 nM, and 90 nM, respectively. It can also inhibit the activity of wild type and V599E mutant BRAF.
Last Update：2022-10-16 17:24:14
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